Publications & Patents
Publications
2023
Reproducibility of pulmonary function tests in patients with systemic sclerosis.
Jacquerie P, André B, de Seny D, Henket M, Giltay L, Ernst M, Louis R, Malaise M, Ribbens C, Guiot J
Sci Rep. 13:18960 (2023)
Lung function impairment, associating hyperinflation with impaired diffusion capacity and transfer coefficient, is a risk factor for hip osteoporosis in patients with chronic obstructive pulmonary disease.
Malaise O, André C, Van Durme C, Seidel L, Schleich F, Louis R, Malaise M, Ribbens C.
J Clin Med.12:2383. (2023)
2022
CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane.
Deroyer C, Poulet C, Paulissen G, Ciregia F, Malaise O, Plener Z, Cobraiville G, Daniel C, Gillet P, Malaise MG, de Seny D
Cellular and Molecular Life Sciences 79:260 (2022)
2021
New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases.
de Seny D, Baiwir D, Bianchi E, Cobraiville G, Deroyer C, Poulet C, Malaise O, Paulissen G, Kaiser MJ, Hauzeur JP, Mazzucchelli G, Delvenne P, Malaise M.
Int J Mol Sci. 23:434. (2021)
Influence of glucocorticoids on cellular senescence hallmarks in osteoarthritic fibroblast-like synoviocytes.
Malaise O, Paulissen G, Deroyer C, Ciregia F, Poulet C, Neuville S, Plener Z, Daniel C, Gillet P, Lechanteur C, Brondello J-M, de Seny D and Malaise M.
J Clin Med. 10:5331. (2021)
Serum IGFBP-2 in systemic sclerosis as a prognostic factor of lung dysfunction.
Guiot J, Njock MS, André B, Gester F, Henket M, de Seny D, Moermans C, Malaise MG, Louis R.
Sci Rep.11:10882. (2021)
A Cross-Sectional and Longitudinal Study to Define Alarmins and A-SAA Variants as Companion Markers in Early Rheumatoid Arthritis.
Ciregia F, Nys G, Cobraiville G, Badot V, Di Romana S, Sidiras P, Sokolova T, Durez P, Fillet M, Malaise MG, de Seny D.
Front Immunol. 12:638814. (2021)
TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells.
Relic B, Deroyer C, Malaise O, Plener Z, Gillet P, de Seny D, Malaise MG.
Biochem J. 478:3145-3155. (2021)
Modulation of αVβ6 integrin in osteoarthritis synovitis and interaction with VTN(381-397 a.a.) competing for TGF-β1 activation.
Ciregia F, Deroyer C, Cobraiville G, Plener Z, Malaise O, Gillet P, Fillet M, Malaise MG, de Seny D.
Experimental & Molecular Medicine 53:210-222. (2021)
2020
Toward diagnostic relevance of the αVβ5, αVβ3, and αVβ6 integrins in OA: expression within human cartilage and spinal osteophytes
Charlier E, Deroyer C, Neuville S, Plener Z, Malaise O, Ciregia F, Gillet P, Reuter G, Salvé M, Withofs N, Hustinx R, de Seny D, Malaise MG.
Bone Res. 8:35. (2020)
Proteins involved in the endoplasmic reticulum stress are modulated in synovitis of osteoarthritis, chronic pyrophosphate arthropathy and rheumatoid arthritis, and correlate with the histological inflammatory score.
de Seny D, Bianchi E, Baiwir D, Cobraiville G, Collin C, Deliège M, Kaiser MJ, Mazzucchelli G, Hauzeur JP, Delvenne P, Malaise MG.
Sci Rep. 10:14159. (2020)
Glycosylation deficiency of lipopolysaccharide-binding protein and corticosteroid-binding globulin associated with activity and response to treatment for rheumatoid arthritis.
Ciregia F, Baiwir D, Cobraiville G, Dewael T, Mazzucchelli G, Badot V, Di Romana S, Sidiras P, Sokolova T, Durez P, Malaise MG, de Seny D.
J Transl Med.18:8. (2020)
Exosomal Long Non-Coding RNAs in Lung Diseases
Poulet C, Njock MS, Moermans C, Louis E, Louis R, Malaise M, Guiot J.
Int J Mol Sci. 21:3580. (2020)
Systematic analysis of COVID-19 infection and symptoms in a systemic lupus erythematosus population: correlation with disease characteristics, hydroxychloroquine use and immunosuppressive treatments
Gendebien Z, von Frenckell C, Ribbens C, André B, Thys M, Gangolf M, Seidel L, Malaise MG, Malaise O.
Annals of the Rheumatic Diseases, 80(6)-94. (2020)
2019
Targeted proteomics reveals serum amyloid A variants and alarmins S100A8-S100A9 as key plasma biomarkers of rheumatoid arthritis.
Nys G, Cobraiville G, Servais AC, Malaise MG, de Seny D, Fillet M.
Talanta. 204:507-517. (2019)
Therapeutic advances in arthritis diseases.
Malaise O, de Seny D.
Biochem Pharmacol. 165:1-3. (2019)
15-Deoxy-Δ-12, 14-prostaglandin J2 acts cooperatively with prednisolone to reduce TGF-β-induced pro-fibrotic pathways in human osteoarthritis fibroblasts.
Vaamonde-Garcia C, Malaise O, Charlier E, Deroyer C, Neuville S, Gillet P, Kurth W, Meijide-Failde R, Malaise MG, de Seny D.
Biochem Pharmacol. 165:66-78. (2019)
Chondrocyte dedifferentiation and osteoarthritis (OA).
Charlier E, Deroyer C, Ciregia F, Malaise O, Neuville S, Plener Z, Malaise M, de Seny D.
Biochem Pharmacol. 165:49-65. (2019)
CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes.
Deroyer C, Charlier E, Neuville S, Malaise O, Gillet P, Kurth W, Chariot A, Malaise M, de Seny D. Cell Death Dis. 10(2):103. (2019)
2018
Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death.
Relic B, Charlier E, Deroyer C, Malaise O, Crine Y, Neuville S, Gillet P, de Seny D, Malaise MG. Oncotarget. (2018) 9(88):35830-35843.
18F- FDG PET/CT joint assessment of early therapeutic response in rheumatoid arthritis patients treated with rituximab.
Fosse P, Kaiser MJ, Namur G, de Seny D, Malaise MG, Hustinx R.
Eur J Hybrid Imaging. (2018) 2(1):6.
2017
Development and validation of novel biomarker assays for osteoarthritis.
Ourradi K, Xu Y, de Seny D, Kirwan J, Blom A, Sharif M.
PLoS One. (2017) 12(7):e0181334.
Validation of a new method by nano-liquid chromatography on chip tandem mass spectrometry for combined quantitation of C3f and the V65 vitronectin fragment as biomarkers of diagnosis and severity of osteoarthritis.
Cobraiville G, Fillet M, Sharif M, Ourradi K, Nys G, Malaise MG, de Seny D.
Talanta. (2017) 169:170-180.
2016
Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis.
Charlier E, Relic B, Deroyer C, Malaise O, Neuville S, Collée J, Malaise MG, De Seny D.
Int J Mol Sci. (2016) 17(12). pii: E2146.
Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts.
Malaise O, Relic B, Charlier E, Zeddou M, Neuville S, Deroyer C, Gillet P, Louis E, Malaise MG, de Seny D. Arthritis Res Ther. (2016) 18(1):219.
Biomarkers of inflammation and innate immunity in atrophic nonunion fracture.
de Seny D, Cobraiville G, Leprince P, Fillet M, Collin C, Mathieu M, Hauzeur JP, Gangji V, Malaise MG. J Transl Med. (2016) 14:258.
BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death. Relic, B., Charlier, E., Deroyer, C., Malaise, O., Neuville, S., Desoroux, A., Gillet, P., de Seny, D., and Malaise, M. G.; Oncotarget (2016) 7(17):23370-82
Restriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and beta-catenin activation. Charlier, E., Malaise, O., Zeddou, M., Neuville, S., Cobraiville, G., Deroyer, C., Sanchez, C., Gillet, P., Kurth, W., de Seny, D., Relic, B., and Malaise, M. G.; Osteoarthritis and Cartilage (2016) 24, 315-324
2015
Use of Tomosynthesis for Detection of Bone Erosions of the Foot in Patients With Established Rheumatoid Arthritis: Comparison With Radiography and CT. Simoni, P., Gerard, L., Kaiser, M. J., Ribbens, C., Rinkin, C., Malaise, O., and Malaise, M.; AJR. American Journal of Roentgenology (2015) 205, 364-370
Selective glucocorticoid receptor modulator compound A, in contrast to prednisolone, does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts. Malaise, O., Relic, B., Quesada-Calvo, F., Charlier, E., Zeddou, M., Neuville, S., Gillet, P., Louis, E., de Seny, D., and Malaise, M. G.; Rheumatology (2015) 54, 1087-1092
Apolipoprotein-A1 as a damage-associated molecular patterns protein in osteoarthritis: ex vivo and in vitro pro-inflammatory properties. de Seny, D., Cobraiville, G., Charlier, E., Neuville, S., Lutteri, L., Le Goff, C., Malaise, D., Malaise, O., Chapelle, J. P., Relic, B., and Malaise, M. G. ; PloS One (2015) 10, e0122904
2014
Umbilical cord fibroblasts: Could they be considered as mesenchymal stem cells? Zeddou, M., Relic, B., and Malaise, M. G.; World Journal of Stem Cells (2014) 6, 367-370
2013
(111)Indium-oxine labelling for evaluating the homing process of autologous osteoblasts implanted percutaneously in atrophic nonunion fractures. Hauzeur, J. P., Bernard, C., Egrise, D., Kurth, W., Van Cauwenberge, H., Lechanteur, C., Gillet, P., Beguin, Y., Malaise, M., and Hustinx, R.; International Orthopaedics (2013) 37, 131-136
Acute-phase serum amyloid A in osteoarthritis: regulatory mechanism and proinflammatory properties. de Seny, D., Cobraiville, G., Charlier, E., Neuville, S., Esser, N., Malaise, D., Malaise, O., Calvo, F. Q., Relic, B., and Malaise, M. G.; PloS One (2013) 8, e66769
2012
Differential signalling through ALK-1 and ALK-5 regulates leptin expression in mesenchymal stem cells. Zeddou, M., Relic, B., Malaise, O., Charlier, E., Desoroux, A., Beguin, Y., de Seny, D., and Malaise, M. G.; Stem Cells and Development (2012) 21, 1948-1955
2011
Discovery and biochemical characterisation of four novel biomarkers for osteoarthritis. de Seny, D., Sharif, M., Fillet, M., Cobraiville, G., Meuwis, M. A., Maree, R., Hauzeur, J. P., Wehenkel, L., Louis, E., Merville, M. P., Kirwan, J., Ribbens, C., and Malaise, M.; Annals of the Rheumatic Diseases (2011) 70, 1144-1152
2010
The umbilical cord matrix is a better source of mesenchymal stem cells (MSC) than the umbilical cord blood. Zeddou, M., Briquet, A., Relic, B., Josse, C., Malaise, M. G., Gothot, A., Lechanteur, C., and Beguin, Y.; Cell Biology International (2010) 34, 693-701
2009
Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts. Relic, B., Zeddou, M., Desoroux, A., Beguin, Y., de Seny, D., and Malaise, M. G.; Laboratory Investigation (2009) 89, 811-822
Contrast-enhanced coded phase-inversion harmonic sonography of knee synovitis correlates with histological vessel density: 2 automated digital quantifications. Kaiser, M. J., Hauzeur, J. P., Blacher, S., Foidart, J. M., Deprez, M., Rossknecht, A., and Malaise, M. G.; The Journal of Rheumatology (2009) 36, 1391-1400
2008
Monomeric calgranulins measured by SELDI-TOF mass spectrometry and calprotectin measured by ELISA as biomarkers in arthritis. de Seny, D., Fillet, M., Ribbens, C., Maree, R., Meuwis, M. A., Lutteri, L., Chapelle, J. P., Wehenkel, L., Louis, E., Merville, M. P., and Malaise, M.; Clinical Chemistry (2008) 54, 1066-1075
2007
Comparison of second- and third-generation anti-cyclic citrullinated peptide antibodies assays for detecting rheumatoid arthritis. Lutteri, L., Malaise, M., and Chapelle, J. P.; Clinica Chimica Acta (2007) 386, 76-81
Further insights in the mechanisms of interleukin-1beta stimulation of osteoprotegerin in osteoblast-like cells. Lambert, C., Oury, C., Dejardin, E., Chariot, A., Piette, J., Malaise, M., Merville, M. P., and Franchimont, N.; Journal of Bone and Mineral Research (2007) 22, 1350-1361
2006
Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis. Relic, B., Benoit, V., Franchimont, N., Kaiser, M. J., Hauzeur, J. P., Gillet, P., Merville, M. P., Bours, V., and Malaise, M. G.; The Journal of Biological Chemistry (2006) 281, 22597-22604
Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature. Olivier, S., Close, P., Castermans, E., de Leval, L., Tabruyn, S., Chariot, A., Malaise, M., Merville, M. P., Bours, V., and Franchimont, N.; Molecular Pharmacology (2006) 69, 1615-1623
(18)F-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3. Beckers, C., Jeukens, X., Ribbens, C., Andre, B., Marcelis, S., Leclercq, P., Kaiser, M. J., Foidart, J., Hustinx, R., and Malaise, M. G.; European Journal of Nuclear Medicine and Molecular Imaging (2006) 33, 275-280
2005
Sodium nitroprusside-induced osteoblast apoptosis is mediated by long chain ceramide and is decreased by raloxifene. Olivier, S., Fillet, M., Malaise, M., Piette, J., Bours, V., Merville, M. P., and Franchimont, N.; Biochemical Pharmacology (2005) 69, 891-901
Interleukin-6: An osteotropic factor influencing bone formation? Franchimont, N., Wertz, S., and Malaise, M.; Bone (2005) 37, 601-606
Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells. Franchimont, N., Lambert, C., Huynen, P., Ribbens, C., Relic, B., Chariot, A., Bours, V., Piette, J., Merville, M. P., and Malaise, M.; Arthritis and Rheumatism (2005) 52, 84-93
Discovery of new rheumatoid arthritis biomarkers using the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry ProteinChip approach. de Seny, D., Fillet, M., Meuwis, M. A., Geurts, P., Lutteri, L., Ribbens, C., Bours, V., Wehenkel, L., Piette, J., Malaise, M., and Merville, M. P.; Arthritis and Rheumatism (2005) 52, 3801-3812
2004
15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. Relic, B., Benoit, V., Franchimont, N., Ribbens, C., Kaiser, M. J., Gillet, P., Merville, M. P., Bours, V., and Malaise, M. G.; The Journal of Biological Chemistry (2004) 279, 22399-22403
Increased expression of receptor activator of NF-kappaB ligand (RANKL), its receptor RANK and its decoy receptor osteoprotegerin in the colon of Crohn's disease patients. Franchimont, N., Reenaers, C., Lambert, C., Belaiche, J., Bours, V., Malaise, M., Delvenne, P., and Louis, E.; Clinical and Experimental Immunology (2004) 138, 491-498
Assessment of disease activity in rheumatoid arthritis with (18)F-FDG PET. Beckers, C., Ribbens, C., Andre, B., Marcelis, S., Kaye, O., Mathy, L., Kaiser, M. J., Hustinx, R., Foidart, J., and Malaise, M. G.; Journal of Nuclear Medicine (2004) 45, 956-964
2003
Rheumatoid hand joint synovitis: gray-scale and power Doppler US quantifications following anti-tumor necrosis factor-alpha treatment: pilot study. Ribbens, C., Andre, B., Marcelis, S., Kaye, O., Mathy, L., Bonnet, V., Beckers, C., and Malaise, M. G.; Radiology (2003) 229, 562-569
2002
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. Ribbens, C., Martin y Porras, M., Franchimont, N., Kaiser, M. J., Jaspar, J. M., Damas, P., Houssiau, F. A., and Malaise, M. G.; Annals of the Rheumatic Diseases (2002) 61, 161-166
TNF-alpha protects human primary articular chondrocytes from nitric oxide-induced apoptosis via nuclear factor-kappaB. Relic, B., Bentires-Alj, M., Ribbens, C., Franchimont, N., Guerne, P. A., Benoit, V., Merville, M. P., Bours, V., and Malaise, M. G. ; Laboratory Investigation (2002) 82, 1661-1672
2001
Relationship between bone mass density and tensile strength of the skin in women. Pierard, G. E., Pierard-Franchimont, C., Vanderplaetsen, S., Franchimont, N., Gaspard, U., and Malaise, M.; European Journal of Clinical Investigation (2001) 31, 731-735
2000
Increased synovial fluid levels of soluble CD23 are associated with an erosive status in rheumatoid arthritis (RA). Ribbens, C., Bonnet, V., Kaiser, M. J., Andre, B., Kaye, O., Franchimont, N., de Groote, D., Beguin, Y., and Malaise, M. G.; Clinical and Experimental Immunology (2000) 120, 194-199
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not. Ribbens, C., Andre, B., Kaye, O., Kaiser, M. J., Bonnet, V., Jaspar, J. M., de Groote, D., Franchimont, N., and Malaise, M. G.; Rheumatology (2000) 39, 1357-1365
Increased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies. Ribbens, C., Andre, B., Kaye, O., Kaiser, M. J., Bonnet, V., de Groote, D., Franchimont, N., and Malaise, M. G.; European Cytokine Network (2000) 11, 669-676
Matrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis. Ribbens, C., Andre, B., Jaspar, J. M., Kaye, O., Kaiser, M. J., De Groote, D., and Malaise, M. G.; The Journal of Rheumatology (2000) 27, 888-893
Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease. Louis, E., Ribbens, C., Godon, A., Franchimont, D., De Groote, D., Hardy, N., Boniver, J., Belaiche, J., and Malaise, M.; Clinical and Experimental Immunology (2000) 120, 241-246
Patents
- 2018: [WO2018007173 (A1)] “Method of early diagnosis of an immune-mediated inflammatory
disease” (European Patent Office: application number WO2017EP65591 20170623).
- 2017: [ES2600052 (T3)] “Biomarkers for osteoarthritis” (European Patent Office: application
number ES20120703569T 20120131).
- 2015: [HK1194140 (A1)] “Markers for impaired bone fracture healing” (European Patent Office:
application number HK20140107430 20140721).
- 2014: [US2014212380 (A1)] “Targets and agents for the treatment of impaired bone fracture
healing” (European Patent Office: application number US201214124165 20120611).
- 2006 [WO2006027321 (A1)] “Identification and use of biomarkers for the diagnosis and the
prognosis of inflammatory diseases” (European Patent Office: application number
WO2005EP54242 20050829).
